期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 106, 期 29, 页码 11972-11977出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0901641106
关键词
actin; brush border; cytoskeleton; microvilli; optical trap
资金
- Vanderbilt Digestive Diseases Research Center [P30 DK-058404]
- Vanderbilt University Medical Center Training Program
- American Heart Association
- National Institutes of Health [R01-DK075555]
All cell functions that involve membrane deformation or a change in cell shape (e. g., endocytosis, exocytosis, cell motility, and cytokinesis) are regulated by membrane tension. While molecular contacts between the plasma membrane and the underlying actin cytoskeleton are known to make significant contributions to membrane tension, little is known about the molecules that mediate these interactions. We used an optical trap to directly probe the molecular determinants of membrane tension in isolated organelles and in living cells. Here, we show that class I myosins, a family of membrane-binding, actin-based motor proteins, mediate membrane/cytoskeleton adhesion and thus, make major contributions to membrane tension. These studies show that class I myosins directly control the mechanical properties of the cell membrane; they also position these motor proteins as master regulators of cellular events involving membrane deformation.
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