期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 106, 期 5, 页码 1313-1317出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0812068106
关键词
MRFM; MRI; nuclear magnetic resonance; molecular structure imaging
资金
- IBM
- National Science Foundation-funded Center [PHY-0425897]
- Swiss National Science Foundation
- Direct For Mathematical & Physical Scien
- Division Of Physics [830228] Funding Source: National Science Foundation
We have combined ultrasensitive magnetic resonance force microscopy (MRFM) with 3D image reconstruction to achieve magnetic resonance imaging (MRI) with resolution < 10 nm. The image reconstruction converts measured magnetic force data into a 3D map of nuclear spin density, taking advantage of the unique characteristics of the resonant slice that is projected outward from a nanoscale magnetic tip. The basic principles are demonstrated by imaging the H-1 spin density within individual tobacco mosaic virus particles sitting on a nanometer-thick layer of adsorbed hydrocarbons. This result, which represents a 100 million-fold improvement in volume resolution over conventional MRI, demonstrates the potential of MRFM as a tool for 3D, elementally selective imaging on the nanometer scale.
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