期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 106, 期 51, 页码 21848-21853出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0911354106
关键词
giant virus; horizontal gene transfer; nucleocytoplasmic large DNA virus; viral evolution
资金
- Centre National de la Recherche Scientifique (CNRS)
- Conventions Industrielles de Formation par la Recherche
- National Institutes of Health National Library of Medicine
- National Institutes of Health [AI11219]
Giant viruses such as Mimivirus isolated from amoeba found in aquatic habitats show biological sophistication comparable to that of simple cellular life forms and seem to evolve by similar mechanisms, including extensive gene duplication and horizontal gene transfer (HGT), possibly in part through a viral parasite, the virophage. We report here the isolation of Marseille virus, a previously uncharacterized giant virus of amoeba. The virions of Marseillevirus encompass a 368-kb genome, a minimum of 49 proteins, and some messenger RNAs. Phylogenetic analysis of core genes indicates that Marseillevirus is the prototype of a family of nucleocytoplasmic large DNA viruses (NCLDV) of eukaryotes. The genome repertoire of the virus is composed of typical NCLDV core genes and genes apparently obtained from eukaryotic hosts and their parasites or symbionts, both bacterial and viral. We propose that amoebae are melting pots of microbial evolution where diverse forms emerge, including giant viruses with complex gene repertoires of various origins.
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