期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 106, 期 21, 页码 8653-8658出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0900850106
关键词
innate immunity; type I IFN; functional cDNA library screening; cytosolic RNA and dsDNA; ER retention signal
资金
- National Natural Science Foundation of China [30772024]
- National Basic Research Program of China [2007CB914502]
- Key Project of Chinese Ministry of Education [108002]
We report here the identification and characterization of a protein, ERIS, an endoplasmic reticulum (ER) IFN stimulator, which is a strong type I IFN stimulator and plays a pivotal role in response to both non-self-cytosolic RNA and dsDNA. ERIS (also known as STING or MITA) resided exclusively on ER membrane. The ER retention/retrieval sequence RIR was found to be critical to retain the protein on ER membrane and to maintain its integrity. ERIS was dimerized on innate immune challenges. Coumermycin-induced ERIS dimerization led to strong and fast IFN induction, suggesting that dimerization of ERIS was critical for self-activation and subsequent downstream signaling.
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