期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 106, 期 22, 页码 9033-9038出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0811827106
关键词
EGCG; microbicide; prostatic acidic phosphatase; SEVI; sexual transmission
资金
- NIH [1G5]
- National Institutes of Health (NIH) AIDS Research and Reference Reagent Program [1819]
- Division of AIDS
- National Institute of Allergy and Infectious Diseases
- Free and Hanseatic City of Hamburg and the Federal Ministry of Health
- Joint United Nations Programme on HIV/AIDS ( UNAIDS) Network for HIV Isolation and Characterization [1693]
- Beatrice Hahn and Feng Gao [2329]
- UNAIDS Network for HIV Isolation and Characterization
- Drs. Agiular-Cordova and Stewart N. Davis [1819]
- TZM-bl cells [8129]
Peptide fragments, derived from prostatic acidic phosphatase, are secreted in large amounts into human semen and form amyloid fibrils. These fibrillar structures, termed semen-derived enhancer of virus infection (SEVI), capture HIV virions and direct them to target cells. Thus, SEVI appears to be an important infectivity factor of HIV during sexual transmission. Here, we are able to demonstrate that epigallocatechin-3-gallate (EGCG), the major active constituent of geen tea, targets SEVI for degradation. Furthermore, it is shown that EGCG inhibits SEVI activity and abrogates semen-mediated enhancement of HIV-1 infection in the absence of cellular toxicity. Therefore, EGCG appears to be a promising supplement to antiretroviral microbicides to reduce sexual transmission of HIV-1.
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