期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 106, 期 32, 页码 13301-13306出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0903825106
关键词
bilayer mechanics; lipid rafts; membrane morphology
资金
- National Science Foundation (NSF) [CMS-0301657, ACI-0204932, CMMI-0748034]
- Nanoscale Interdisciplinary Research Teams [CMS-0404031]
- National Institutes of Health [RO1 GM084211]
- Directorate For Engineering [748034] Funding Source: National Science Foundation
- Div Of Civil, Mechanical, & Manufact Inn [748034] Funding Source: National Science Foundation
Cellular membranes are a heterogeneous mix of lipids, proteins and small molecules. Special groupings enriched in saturated lipids and cholesterol form liquid-ordered domains, known as lipid rafts, thought to serve as platforms for signaling, trafficking and material transport throughout the secretory pathway. Questions remain as to how the cell maintains small fluid lipid domains, through time, on a length scale consistent with the fact that no large-scale phase separation is observed. Motivated by these examples, we have utilized a combination of mechanical modeling and in vitro experiments to show that membrane morphology plays a key role in maintaining small domain sizes and organizing domains in a model membrane. We demonstrate that lipid domains can adopt a flat or dimpled morphology, where the latter facilitates a repulsive interaction that slows coalescence and helps regulate domain size and tends to laterally organize domains in the membrane.
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