4.8 Article

AMP-activated protein kinase adapts rRNA synthesis to cellular energy supply

出版社

NATL ACAD SCIENCES
DOI: 10.1073/pnas.0909873106

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AMPK; glucose deprivation; RNA polymerase I; TIF-IA; transcription

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  1. Deutsche Forschungsgemeinschaft
  2. European Union Network Epigenome''
  3. Fonds der Chemischen Industrie

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AMP-activated protein kinase (AMPK) senses changes in the intracellular AMP/ATP ratio, switching off energy-consuming processes and switching on catabolic pathways in response to energy depletion. Here, we show that AMPK down-regulates rRNA synthesis under glucose restriction by phosphorylating the RNA polymerase I (Pol I)-associated transcription factor TIF-IA at a single serine residue (Ser-635). Phosphorylation by AMPK impairs the interaction of TIF-IA with the TBP-containing promoter selectivity factor SL1, thereby precluding the assembly of functional transcription initiation complexes. Mutation of Ser-635 compromises down-regulation of Pol I transcription in response to low energy supply, supporting that activation of AMPK adapts rRNA synthesis to nutrient availability and the cellular energy status.

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