期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 106, 期 38, 页码 16257-16262出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0902150106
关键词
BRDT; chromatin; FRET; HDAC inhibitor
资金
- Grant-in-aid for Scientific Research on Priority Areas
- CREST Research Project, JST
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- ANRblanc Episperm & Empreinte, INCa, and ARC-ARECA research programs
To visualize histone acetylation in living cells, we developed a genetically encoded fluorescent resonance energy transfer ( FRET)based indicator. Response of the indicator reflects changes in the acetylation state of both K5 and K8 in histone H4. Using this acetylation indicator, we were able to monitor the dynamic fluctuation of histone H4 acetylation levels during mitosis, as well as acetylation changes in response to structurally distinct histone deacetylase inhibitors.
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