期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 107, 期 3, 页码 1196-1200出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0908189107
关键词
addiction; basal ganglia; motivation; food; rat
资金
- French National Centre for Scientific Research (CNRS)
- National Agency for Research (ANR) [JC05_48262]
- Interministerial Mission for the fight against drugs and drug addiction (MILDT)-National Institute of Health and Medical Research (-INSERM)-Institute of Cancer (InCa) [MIL 0701]
- Foundation for Brain Research (FRC)
Deep brainstimulation (DBS) is a reversible technique that is currently used for the treatment of Parkinson disease and may be suitable for the treatment of psychiatric disorders. Whether DBS inactivates the target structure is still a matter of debate. Here, from findings obtained in rats, we propose DBS of the subthalamic nucleus (STN) as a possible treatment for cocaine addiction to be further tested in human studies. We show that STN DBS reversibly reduces the motivation to work for an i.v. injection of cocaine, and it increases motivation to work for sucrose pellets. These opposite effects may result from STN DBS effect on the positive affective properties of these rewards. Indeed, we further show that STN DBS reduces the preference for a place previously associated with the rewarding properties of cocaine, and it increases the preference for a place associated with food. Because these findings are consistent with those observed after STN lesions [Baunez C, Dias C, Cador M, Amalric M(2005) Nat Neurosci 8: 484-489], they suggest that STN DBS mimics an inactivation of the STN on motivational processes. Furthermore, given that one of the major challenges for cocaine addiction is to find a treatment that reduces the craving for the drug without diminishing the motivation for naturally rewarding activities, our findings validate STN as a good target and DBS as the appropriate technique for a promising therapeutic strategy in the treatment of cocaine addiction.
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