期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 106, 期 47, 页码 20016-20020出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0908789106
关键词
eating disorders; obesity; palatability; palatable food dependence; withdrawal
资金
- National Institute of Diabetes and Digestive and Kidney Diseases [DK70118, DK26741, P30DK56336]
- National Institute on Drug Abuse [DA023680]
- National Institute on Alcohol Abuse and Alcoholism [AA016731, AA015566]
- National Institute of Neurological Disorders and Stroke [IT32NS061847-01A2]
- National Institute on Aging [AG028040]
- National Heart, Lung and Blood Institute [HL088083]
- Ellison Medical Foundation
- Pearson Center for Alcoholism and Addiction Research
- National Institute on Drug Abuse
- National Institute on Alcohol Abuse and Alcoholism
Dieting to control body weight involves cycles of deprivation from palatable food that can promote compulsive eating. The present study shows that rats withdrawn from intermittent access to palatable food exhibit overeating of palatable food upon renewed access and an affective withdrawal-like state characterized by corticotropin-releasing factor-1 (CRF1) receptor antagonist-reversible behaviors, including hypophagia, motivational deficits to obtain less palatable food, and anxiogenic-like behavior. Withdrawal was accompanied by increased CRF expression and CRF1 electrophysiological responsiveness in the central nucleus of the amygdala. We propose that recruitment of anti-reward extrahy-pothalamic CRF-CRF1 systems during withdrawal from palatable food, analogous to abstinence from abused drugs, may promote compulsive selection of palatable food, undereating of healthier alternatives, and a negative emotional state when intake of palatable food is prevented.
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