4.8 Article

Color-tuned neurons are spatially clustered according to color preference within alert macaque posterior inferior temporal cortex

出版社

NATL ACAD SCIENCES
DOI: 10.1073/pnas.0810943106

关键词

column; cone; functional MRI; functional architecture; primate

资金

  1. Alexander von Humboldt Foundation
  2. German Ministry of Science [01GO0506]
  3. Neuroscience Program
  4. Wellesley College
  5. Whitehall Foundation
  6. Direct For Biological Sciences
  7. Division Of Integrative Organismal Systems [0918064] Funding Source: National Science Foundation

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Large islands of extrastriate cortex that are enriched for color-tuned neurons have recently been described in alert macaque using a combination of functional magnetic resonance imaging (fMRI) and single-unit recording. These millimeter-sized islands, dubbed globs,'' are scattered throughout the posterior inferior temporal cortex (PIT), a swath of brain anterior to area V3, including areas V4, PITd, and posterior TEO. We investigated the micro-organization of neurons within the globs. We used fMRI to identify the globs and then used MRI-guided microelectrodes to test the color properties of single glob cells. We used color stimuli that sample the CIELUV perceptual color space at regular intervals to test the color tuning of single units, and make two observations. First, color-tuned neurons of various color preferences were found within single globs. Second, adjacent glob cells tended to have the same color tuning, demonstrating that glob cells are clustered by color preference and suggesting that they are arranged in color columns. Neurons separated by 50 mu m, measured parallel to the cortical sheet, had more similar color tuning than neurons separated by 100 mu m, suggesting that the scale of the color columns is < 100 mu m. These results show that color-tuned neurons in PIT are organized by color preference on a finer scale than the scale of single globs. Moreover, the color preferences of neurons recorded sequentially along a given electrode penetration shifted gradually in many penetrations, suggesting that the color columns are arranged according to a chromotopic map reflecting perceptual color space.

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