期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 106, 期 29, 页码 12001-12006出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0902903106
关键词
alpha-ketoglutarate dehydrogenase; avian; extinction; transketolase
资金
- Signhild Engkvists Stiftelse
- Stiftelsen Olle Engkvist Byggmastare
- Vanerns vattenvardsforbund
- Stockholm Vatten
- Sormlands Sparbank
- Stockholm County Council
- County Administrative Board of Sodermanland
- Swedish Environmental Protection Agency
Wild birds of several species are dying in large numbers from an idiopathic paralytic disease in the Baltic Sea area. Here, we demonstrate strong relationships between this disease, breeding failure, and thiamine (vitamin B(1)) deficiency in eggs, pulli, and full-grown individuals. Thiamine is essential for vertebrates, and its diphosphorylated form functions as a cofactor for several life sustaining enzymes, whereas the triphosphorylated form is necessary for the functioning of neuronal membranes. Paralyzed individuals were remedied by thiamine treatment. Moreover, thiamine deficiency and detrimental effects on thiamine-dependent enzymes were demonstrated in the yolk, liver, and brain. We propose that the mortality and breeding failure are part of a thiamine deficiency syndrome, which may have contributed significantly to declines in many bird populations during the last decades.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据