期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 106, 期 29, 页码 11913-11918出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0812138106
关键词
evolution; nuclear-receptor ligand; steroidogenesis
资金
- Ministere de l'Education Nationale, de la Recherche et de la Technologie [FOOD-CT-2003-506319]
- Ecole Normale Superieur e de Lyon
- Centre National de la Recherche Scientifique
Steroid hormones regulate many physiological processes in vertebrates, nematodes, and arthropods through binding to nuclear receptors (NR), a metazoan-specific family of ligand-activated transcription factors. The main steps controlling the diversification of this family are now well-understood. In contrast, the origin and evolution of steroid ligands remain mysterious, although this is crucial for understanding the emergence of modern endocrine systems. Using a comparative genomic approach, we analyzed complete metazoan genomes to provide a comprehensive view of the evolution of major enzymatic players implicated in steroidogenesis at the whole metazoan scale. Our analysis reveals that steroidogenesis has been independently elaborated in the 3 main bilaterian lineages, and that steroidogenic cytochrome P450 enzymes descended from those that detoxify xenobiotics.
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