4.8 Article

A gain in GABAA receptor synaptic strength in thalamus reduces oscillatory activity and absence seizures

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NATL ACAD SCIENCES
DOI: 10.1073/pnas.0811326106

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benzodiazepine; epilepsy; inhibition; knockout

资金

  1. National Institutes of Health Epilepsy Training [NS007280]
  2. National Institutes of Health Grant [NS006477]

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Neural inhibition within the thalamus is integral in shaping thalamocortical oscillatory activity. Fast, synaptic inhibition is primarily mediated by activation of heteropentameric GABA(A) receptor complexes. Here, we examined the synaptic physiology and network properties of mice lacking GABAA receptor alpha 3, a subunit that in thalamus is uniquely expressed by inhibitory neurons of the reticular nucleus (nRT). Deletion of this subunit produced a powerful compensatory gain in inhibitory postsynaptic response in nRT neurons. Although, other forms of inhibitory and excitatory synaptic transmission in the circuit were unchanged, evoked thalamic oscillations were strongly dampened in alpha 3 knockout mice. Furthermore, pharmacologically induced thalamocortical absence seizures displayed a reduction in length and power in alpha 3 knockout mice. These studies highlight the role of GABAergic inhibitory strength within nRT in the maintenance of thalamic oscillations, and demonstrate that inhibitory intra-nRT synapses are a critical control point for regulating higher order thalamocortical network activity.

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