期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 106, 期 35, 页码 14966-14971出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0900527106
关键词
caveolin; exocytosis; signaling; urinary tract infection; uropathogenic Escherichia coli
资金
- National Institutes of Health [AI050021, DK077159, DK077307, DK62863, DK050814]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI050021] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P01DK053369, R01DK050814, R37DK050814, R21DK077307, R01DK077159, R01DK062863] Funding Source: NIH RePORTER
Uropathogenic Escherichia coli invade bladder epithelial cells (BECs) by direct entry into specialized cAMP regulated exocytic compartments. Remarkably, a significant number of these intracellular bacteria are subsequently expelled in a nonlytic and piecemeal fashion by infected BECs. Here, we report that expulsion of intracellular E. coli by infected BECs is initiated by the pattern recognition receptor, Toll-like receptor (TLR) 4, after activation by LPS. Also, we reveal that caveolin-1, Rab27b, PKA, and MyRIP are components of the exocytic compartment, and that they form a complex involved in the exocytosis of bacteria. This capacity of TLR4 to mediate the expulsion of intracellular bacteria from infected cells represents a previously unrecognized function for this innate immune receptor.
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