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Julian J. Lum et al.
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R Namba et al.
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NCM Hearle et al.
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High proportion of large genomic STK11 deletions in Peutz-Jeghers syndrome
S Aretz et al.
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A Dekanty et al.
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CM Johannessen et al.
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HG Wendel et al.
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RJ Shaw et al.
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HER2 signaling enhances 5′UTR-mediated translation of c-Myc mRNA
E Galmozzi et al.
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MN Corradetti et al.
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PK Majumder et al.
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Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene
J Carretero et al.
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HB Zhang et al.
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H Onda et al.
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DJ Rossi et al.
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E Laughner et al.
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