期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 106, 期 31, 页码 13040-13045出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0905267106
关键词
brain connectivity; BrainMap; FMRI; functional connectivity; resting-state networks
资金
- Engineering and Physical Sciences Research Council/Royal Academy of Engineering
- Human Brain Project
- National Institute of Mental Health [R01-MH074457-01A1]
- Engineering and Physical Sciences Research Council [EP/D001935/1] Funding Source: researchfish
- Medical Research Council [MC_U120097117] Funding Source: researchfish
Neural connections, providing the substrate for functional networks, exist whether or not they are functionally active at any given moment. However, it is not known to what extent brain regions are continuously interacting when the brain is at rest.'' In this work, we identify the major explicit activation networks by carrying out an image-based activation network analysis of thousands of separate activation maps derived from the BrainMap database of functional imaging studies, involving nearly 30,000 human subjects. Independently, we extract the major covarying networks in the resting brain, as imaged with functional magnetic resonance imaging in 36 subjects at rest. The sets of major brain networks, and their decompositions into subnetworks, show close correspondence between the independent analyses of resting and activation brain dynamics. We conclude that the full repertoire of functional networks utilized by the brain in action is continuously and dynamically active'' even when at rest.''
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