期刊
EXPERIMENTAL AND THERAPEUTIC MEDICINE
卷 9, 期 6, 页码 2133-2136出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/etm.2015.2393
关键词
hepatoid adenocarcinoma; stomach
Hepatoid adenocarcinoma (HAC) is a rare form of gastric cancer that has unique clinicopathological features and an extremely poor prognosis. The present case report describes a patient who was referred to the No. 461 Hospital of PLA (Changchun, China) due to nausea and occasional vomiting of acid/water. The patient was diagnosed with gastric signet-ring cell carcinoma and surgery was recommended. A total gastrectomy was performed on the operable lesion. Histopathological analysis revealed that the tumors exhibited two pathological changes: HAC and signet-ring cell carcinoma differentiation. Furthermore, the tumor cells were immunohistochemically positive for alpha-fetoprotein, cytokeratin low/high molecular weight, Cam5.2, cytokeratin 7, p53, epithelial membrane antigen and carcinoembryonic antigen. Previous studies and our experience have suggested that HAC is an aggressive type of adenocarcinoma; however, radical surgery and chemotherapy may positively impact clinical outcomes.
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