期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 106, 期 34, 页码 14265-14270出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0900162106
关键词
Chip chip; PC4; reinitiation; TFIIIB
资金
- French National Research Agency [ANR-07-BLAN-0039-01]
- Association pour la Recherche contre le Cancer [1078]
- Commissariat a l'Energie Atomique
- Agence Nationale de la Recherche (ANR) [ANR-07-BLAN-0039] Funding Source: Agence Nationale de la Recherche (ANR)
Human PC4 and the yeast ortholog Sub1 have multiple functions in RNA polymerase II transcription. Genome-wide mapping revealed that Sub1 is present on Pol III-transcribed genes. Sub1 was found to interact with components of the Pol III transcription system and to stimulate the initiation and reinitiation steps in a system reconstituted with all recombinant factors. Sub1 was required for optimal Pol III gene transcription in exponentially growing cells.
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