期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 107, 期 1, 页码 338-343出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0912652107
关键词
epilepsy; fast ripple oscillation; ripple oscillation
资金
- MRC Milstein Fund (UK)
- Wolfson Foundation
- Royal Society
- Newcastle Upon Tyne Healthcare Charities Trust
- NIH/NINDS
- Alexander von Humboldt Stiftung
- EPSRC [EP/E002331/1]
- Engineering and Physical Sciences Research Council [EP/G03950X/1] Funding Source: researchfish
- Medical Research Council [G0701048] Funding Source: researchfish
- EPSRC [EP/G03950X/1] Funding Source: UKRI
- MRC [G0701048] Funding Source: UKRI
Very fast oscillations (VFOs, >80 Hz) are important for physiological brain processes and, in excess, with certain epilepsies. Putative mechanisms for VFO include interneuron spiking and network activity in coupled pyramidal cell axons. It is not known whether either, or both, of these apply in pathophysiological conditions. Spontaneously occurring interictal discharges occur in human tissue in vitro, resected from neocortical epileptic foci. VFO associated with these discharges was manifest in both field potential and, with phase delay, in excitatory synaptic inputs to fast spiking interneurons. Recruitment of somatic pyramidal cell and interneuron spiking was low, with no correlation between VFO power and synaptic inputs to principal cells. Reducing synaptic inhibition failed to affect VFO occurrence, but they were abolished by reduced gap junction conductance. These data suggest a lack of a causal role for interneurons, and favor a nonsynaptic pyramidal cell network origin for VFO in epileptic human neocortex.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据