4.8 Article

Clathrin adaptor AP-1 complex excludes multiple postsynaptic receptors from axons in C. elegans

出版社

NATL ACAD SCIENCES
DOI: 10.1073/pnas.0812078106

关键词

polarity; trafficking; glutamate receptor; dendrite

资金

  1. Howard Hughes Medical Institute
  2. Human Frontier Science Foundation
  3. W. M. Keck Foundation
  4. Stanford Medical Scientist Training Program
  5. National Institutes of Health [GM007365]
  6. National Science Foundation Graduate Research Fellowship
  7. Stanford Graduate Fellowship

向作者/读者索取更多资源

Neurons are highly polarized cells with morphologically and molecularly distinct axonal and dendritic compartments. It is not well understood how postsynaptic receptors are selectively enriched in dendrites in vivo. We investigated the molecular mechanisms of dendritically polarized localization of a glutamate receptor, an acetylcholine receptor, and a ROR-type receptor tyrosine kinase in the interneuron RIA in C. elegans. We found that the clathrin adaptor AP-1 complex mu 1 subunit UNC-101 functions cell autonomously to maintain the correct localization of these receptors in a dynamin-dependent manner. In unc-101 mutants, instead of being dendritically enriched, all 3 receptors are evenly distributed in the axonal and dendritic compartments. Surprisingly, UNC-101 predominantly localizes to the axonal compartment, suggesting a possible transcytosis model for the dendritic targeting of neurotransmitter receptors.

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