期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 106, 期 6, 页码 1886-1891出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0812945106
关键词
cancer genome; transcriptome sequencing
资金
- Conrad N. Hilton Foundation
- Ludwig Institute for Cancer Research
- MRC [G0600705] Funding Source: UKRI
- Medical Research Council [G0600705] Funding Source: researchfish
We have identified new genomic alterations in the breast cancer cell line HCC1954, using high-throughput transcriptome sequencing. With 120 Mb of cDNA sequences, we were able to identify genomic rearrangement events leading to fusions or truncations of genes including MRE11 and NSD1, genes already implicated in oncogenesis, and 7 rearrangements involving other additional genes. This approach demonstrates that high-throughput transcriptome sequencing is an effective strategy for the characterization of genomic rearrangements in cancers.
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