期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 106, 期 45, 页码 18890-18896出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0910659106
关键词
neural development; retrograde signaling; synaptic plasticity; retinal ganglion cell
资金
- National Institutes of Health [EY01979, NS36999]
- National Basic Research of China [2006CB806605, 2006CB943802]
Neural activity can induce persistent strengthening or weakening of synapses, known as long-term potentiation (LTP) or long-term depression (LTD), respectively. As potential cellular mechanisms underlying learning and memory, LTP and LTD are generally regarded as synapse-specific imprints'' of activity, although there is evidence in vitro that LTP/LTD may spread to adjacent synapses. Here, we report that LTP and LTD induced in vivo at retinotectal synapses of Xenopus tadpoles undergo rapid long-range retrograde spread from the optic tectum to the retina, resulting in potentiation and depression of bipolar cell synapses on the dendrites of retinal ganglion cells, respectively. The retrograde spread of LTP and LTD required retrograde signaling initiated by brain-derived neurotrophic factor and nitric oxide in the tectum, respectively. Such bidirectional adjustment of the strength of input synapses in accordance to that of output synapses may serve to coordinate developmental refinement and learning functions of neural circuits.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据