期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 106, 期 37, 页码 15756-15761出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0900862106
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资金
- Swedish Cancer Society, Swedish Medical Research Council
- Gustaf V Jubilee Fund and Karolinska Institutet
- Danish Research Council for Nature and Universe
- Carlsberg Foundation
- Ase and Ejnar Danielsens Foundation
- Becket Foundation
- Einar Willumsens Foundation
- Karen Elise Jensens Foundation
The p53 target gene Wig-1 encodes a double-stranded-RNA-binding zinc finger protein. We show here that Wig-1 binds to p53 mRNA and stabilizes it through an AU-rich element ( ARE) in the 3' UTR of the p53 mRNA. This effect is mirrored by enhanced p53 protein levels in both unstressed cells and cells exposed to p53-activating stress agents. Thus, the p53 target Wig-1 is a previously undescribed ARE-regulating protein that acts as a positive feedback regulator of p53, with implications both for the steady-state levels of p53 and for the p53 stress response. Our data reveal a previously undescribed link between the tumor suppressor p53 and posttranscriptional gene regulation via AREs in mRNA.
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