期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 105, 期 44, 页码 17046-17049出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0806560105
关键词
developmental origins; DNA methylation; insulin-like growth factor II; nutrition; periconception
资金
- Netherlands Heart Foundation [200613083]
- U.S. National Institutes of Health [RO1-HL067914]
- Netherlands Organization for Scientific Research NWO [911-03-016]
- European Union-funded Network of Excellence LifeSpan [FP6 036894]
Extensive epidemiologic studies have suggested that adult disease risk is associated with adverse environmental conditions early in development. Although the mechanisms behind these relationships are unclear, an involvement of epigenetic dysregulation has been hypothesized. Here we show that individuals who were prenatally exposed to famine during the Dutch Hunger Winter in 1944-45 had, 6 decades later, less DNA methylation of the imprinted IGF2 gene compared with their unexposed, same-sex siblings. The association was specific for periconceptional exposure, reinforcing that very early mammalian development is a crucial period for establishing and maintaining epigenetic marks. These data are the first to contribute empirical support for the hypothesis that early-life environmental conditions can cause epigenetic changes in humans that persist throughout life.
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