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SK Chan et al.
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DW Bell et al.
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Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants
H Greulich et al.
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TA Carter et al.
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W Pao et al.
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HR Tsou et al.
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AF Gazdar et al.
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R Sordella et al.
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AW Schüttelkopf et al.
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Coot:: model-building tools for molecular graphics
P Emsley et al.
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JG Paez et al.
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Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor
J Stamos et al.
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NP Shah et al.
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C Roche-Lestienne et al.
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RJ Read
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