期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 105, 期 49, 页码 19199-19204出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0810634105
关键词
enhancement of gene expression; nuclear architecture; chromosomal movement; interchromosomal interactions; SC35 domains
资金
- Cancer Research Institute
- American- Italian Cancer Foundation Postdoctoral Research Fellowship
- National Institutes of Health [CA52599, HL088129, GM049369, CA114184, CA97134, DK39949, NS034934, HL65445, DK018477, W81XWH- 07-PCRP-IDA, W81XWH-08-1-0665]
Although the role of liganded nuclear receptors in mediating coactivator/corepressor exchange is well-established, little is known about the potential regulation of chromosomal organization in the 3-dimensional space of the nucleus in achieving integrated transcriptional responses to diverse signaling events. Here, we report that ligand induces rapid interchromosomal interactions among specific subsets of estrogen receptor alpha-bound transcription units, with a dramatic reorganization of nuclear territories, which depends on the actions of nuclear actin/myosin-I machinery and dynein light chain 1. The histone lysine demethylase, LSD1, is required for these ligand-induced interactive loci to associate with distinct interchromatin granules, long thought to serve as storage'' sites for the splicing machinery, some critical transcription elongation factors, and various chromatin remodeling complexes. We demonstrate that this 2-step nuclear rearrangement is essential for achieving enhanced, coordinated transcription of nuclear receptor target genes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据