期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 105, 期 39, 页码 15070-15075出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0804326105
关键词
Streptococcus milleri; oropharyngeal flora; normal microbiota; microbial communities
资金
- Canadian Cystic Fibrosis Foundation
- Alberta Heritage Foundation for Medical Research Scientist and Canada Research Chair in Microbial Gene Expression
- Alberta Heritage Foundation for Medical Research
- Canadian Institutes of Health Research
Lung disease is the leading cause of morbidity and mortality in cystic fibrosis (CF) patients. A modest number of bacterial pathogens have been correlated with pulmonary function decline; however, microbiological and molecular evidence suggests that CF airway infection is polymicrobial. To obtain a more complete assessment of the microbial community composition and dynamics, we undertook a longitudinal study by using culture-independent and microbiological approaches. In the process, we demonstrated that within complex and dynamic communities, the Streptococcus milleri group (SMG) can establish chronic pulmonary infections and at the onset of 39% of acute pulmonary exacerbations, SMG is the numerically dominant pathogen. We report the comprehensive polymicrobial community dynamics of a CF lung infection in a clinically relevant context. If a given organism, such as Pseudomonas aeruginosa, becomes resistant to antibiotic therapy, an alternative treatment avenue may mediate the desired clinical response by effectively managing the composition of the microbial community.
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