期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 105, 期 37, 页码 14157-14162出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0806658105
关键词
adult neurogenesis; synaptogenesis; DISC1; hippocampus; axon guidance
资金
- National Institutes of Health [NS047344, AG024984, MH084018, NS048271, HD045757]
- McKnight Scholar Award
- Robert Packard Center for ALS Research
- Muscular Dystrophy Association
- Rett Syndrome Research Foundation
- Simons Foundation
- Klingenstein Fellowship Award in the Neurosciences
- March of Dimes Foundation
- Adelson Medical Research Foundation
- Whitehall Foundation
New neurons are continuously generated in restricted regions of the adult mammalian brain. Although these adult-born neurons have been shown to receive synaptic inputs, little is known about their synaptic outputs. Using retrovirus-mediated birth-dating and labeling in combination with serial section electron microscopic reconstruction, we report that mossy fiber en passant boutons of adult-born dentate granule cells form initial synaptic contacts with CA3 pyramidal cells within 2 weeks after their birth and reach morphologic maturity within 8 weeks in the adult hippocampus. Knockdown of Disrupted-in-Schizophrenia-1 (DISC1) in newborn granule cells leads to defects in axonal targeting and development of synaptic outputs in the adult brain. Together with previous reports of synaptic inputs, these results demonstrate that adult-born neurons are fully integrated into the existing neuronal circuitry. Our results also indicate a role for DISC1 in presynaptic development and may have implications for the etiology of schizophrenia and related mental disorders.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据