期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 105, 期 34, 页码 12108-12112出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0803147105
关键词
methylmercury; thimerosal; x-ray fluorescence mapping; eye lens
资金
- DOE OBES
- DOE OBER
- NIH NCRR BTP
- NSERC
- NRC
- CIHR
- University of Saskatchewan
Using synchrotron x-ray fluorescence mapping, we have examined the uptake and localization of organic mercury in zebrafish larvae. Strikingly, the greatest accumulation of methyl and ethyl mercury compounds was highly localized in the rapidly dividing lens epithelium, with lower levels going to brain, optic nerve, and various other organs. The data suggest that the reported impairment of visual processes by mercury may arise not only from previously reported neurological effects, but also from direct effects on the ocular tissue. This novel approach is a powerful tool for directly investigating the molecular toxicology of heavy metals, and should be equally applicable to the study of a wide range of elements in developing embryos.
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