期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 105, 期 45, 页码 17469-17474出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0809527105
关键词
homeobox protein; host-pathogen interactions; Staphylococcus aureus
资金
- National Institutes of Health [DK43351, DK57521, AI062773, AI064332]
- National Center for Research Resources
- Jane Coffin Childs Memorial
We used the model nematode Caenorhabditis elegans infected with the human pathogen Staphylococcus aureus to identify components of epithelial immunity. Transcriptional profiling and reverse genetic analysis revealed that mutation of the C elegans beta-catenin homolog bar-1 or the downstream homeobox gene egl-5 results in a defective response and hypersensitivity to S. aureus infection. Epistasis analysis showed that bar-1 and egi-5 function in parallel to previously described C elegans immune-response pathways. Overexpression of human homologs of egl-5 modulated NF-kappa B-dependent TLR2 signaling in epithelial cells. These data suggest that beta-catenin and homeobox genes play an important and conserved role in innate immune defense.
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