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Stop codon recognition by release factors induces structural rearrangement of the ribosomal decoding center that is productive for peptide release
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Two distinct components of release factor function uncovered by nucleophile partitioning analysis
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An intact ribose moiety at A2602 of 23S rRNA is key to trigger peptidyl-tRNA hydrolysis during translation termination
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Structure of the 70S ribosome complexed with mRNA and tRNA
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Interactions of the release factor RF1 with the ribosome as revealed by cryo-EM
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Crystal structures of the ribosome in complex with release factors RF1 and RF2 bound to a cognate stop codon
S Petry et al.
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Involvement of 16S rRNA Nucleotides G1338 and A1339 in discrimination of initiator tRNA
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Energetic and structural consequences of perturbing Gly-193 in the oxyanion hole of serine proteases
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Crystal structures of complexes between aminoglycosides and decoding A site oligonucleotides: role of the number of rings and positive charges in the specific binding leading to miscoding
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Electrostatic potential of nucleotide-free protein is sufficient for discrimination between adenine and guanine-specific binding sites
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Structural analyses of peptide release factor 1 from Thermotoga maritima reveal domain flexibility required for its interaction with the ribosome
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The active site of the ribosome is composed of two layers of conserved nucleotides with distinct roles in peptide bond formation and peptide release
EM Youngman et al.
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High resolution crystal structures of human Rab5a and five mutants with substitutions in the catalytically important phosphate-binding loop
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A cryo-electron microscopic study of ribosome-bound termination factor RF2
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The critical role of the universally conserved A2602 of 23S ribosomal RNA in the release of the nascent peptide during translation termination
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Release of peptide promoted by the GGQ motif of class 1 release factors regulates the GTPase activity of RF3
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Bacterial polypeptide release factor RF2 is structurally distinct from eukaryotic eRF1
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Class-1 translation termination factors: invariant GGQ minidomain is essential for release activity and ribosome binding but not for stop codon recognition
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X-ray snapshots of serine protease catalysis reveal a tetrahedral intermediate
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Recognition of cognate transfer RNA by the 30S ribosomal subunit
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Crystal structure of an initiation factor bound to the 30S ribosomal subunit
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The accuracy of codon recognition by polypeptide release factors
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A tripeptide 'anticodon' deciphers stop codons in messenger RNA
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The crystal structure of human eukaryotic release factor eRF1 - Mechanism of stop codon recognition and peptidyl-tRNA hydrolysis
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GTPase mechanism and function: new insights from systematic mutational analysis of the phosphate-binding loop residue Ala(30) of Rab5
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