期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 105, 期 51, 页码 20063-20066出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0806007105
关键词
Drosophila development; regulatory subcircuits; genomic regulatory logic; sea urchin development
资金
- National Academy of Sciences Sackler Colloquium
- National Institutes of Health [HD37105, GM34431]
The modular components, or subcircuits, of developmental gene regulatory networks (GRNs) execute specific developmental functions, such as the specification of cell identity. We survey examples of such subcircuits and relate their structures to corresponding developmental functions. These relations transcend organisms and genes, as illustrated by the similar structures of the subcircuits controlling the specification of the mesectoderm in the Drosophila embryo and the endomesoderm in the sea urchin, even though the respective subcircuits are composed of nonorthologous regulatory genes.
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