期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 105, 期 21, 页码 7506-7510出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0711127105
关键词
aging; behavior; neurogenetics; stress resistance
资金
- NINDS NIH HHS [R01 NS026528-17, R01 NS026528-15, NS26528, R01 NS026528-16, R01 NS026528] Funding Source: Medline
Beneficial effects of social interaction on aging have been studied in humans and other species. We found that short-lived Drosophila mutants of the antioxidant enzyme Cu/Zn superoxide dismutase displayed a robust lifespan extension, with improved stress resistance and motor ability, upon cohousing with active flies of longer lifespan or younger age. Genetic, surgical, and environmental manipulations revealed motor and sensory components in behavioral interactions required for the lifespan extension induced by cohousing. Our results provide a definitive case of beneficial social interaction on lifespan and a useful entry point for analyzing the underlying molecular networks and physiological mechanisms.
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