期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 105, 期 14, 页码 5614-5619出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0801689105
关键词
dopamine receptor-1; microRNAs; striatum; Rett syndrome; clasping
资金
- NIDA NIH HHS [R03-DA022201, R03 DA022201, R03 DA022201-01, R03 DA022201-02] Funding Source: Medline
- NIMH NIH HHS [R21-MH083090, R21 MH083090] Funding Source: Medline
- NINDS NIH HHS [K08 NS050110-01, K08 NS050110] Funding Source: Medline
MicroRNAs(miRNAs) are small noncoding RNAs that can act to repress target mRNAs by suppressing translation and/or reducing mRNA stability. Although it is clear that miRNAs and Dicer, an RNase III enzyme that is central to the production of mature miRNAs, have a role in the early development of neurons, their roles in the postmitotic neuron in vivo are largely unknown. To determine the roles of Dicer in neurons, we ablated Dicer in dopaminoceptive neurons. Mice that have lost Dicer in these cells display a range of phenotypes including ataxia, front and hind limb clasping, reduced brain size, and smaller neurons. Surprisingly, dopaminoceptive neurons without Dicer survive over the life of the animal. The lack of profound cell death contrasts with other mouse models in which Dicer has been ablated. These studies highlight the complicated nature of Dicerablation in the brain and provide a useful mouse model for studying dopaminoceptive neuron function.
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