期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 105, 期 41, 页码 15660-15665出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0808606105
关键词
functional model; NO reduction; N2O; trans mechanism
资金
- National Institutes of Health [GM-69658]
- National Science Foundation [DMB0342807]
A functional heme/nonheme nitric oxide reductase (NOR) model is presented. The fully reduced diiron compound reacts with two equivalents of NO leading to the formation of one equivalent of N2O and the bis-ferric product. NO binds to both heme Fe and nonheme Fe complexes forming individual ferrous nitrosyl species. The mixed-valence species with an oxidized heme and a reduced nonheme Fe-B does not show NO reduction activity. These results are consistent with a so-called trans mechanism for the reduction of NO by bacterial NOR.
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