期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 105, 期 51, 页码 20072-20076出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0806476105
关键词
Drosophila; regulatory code; embryo; morphogen
资金
- Moore Foundation
- National Institutes of Health
Gradients of extracellular signaling molecules and transcription factors are used in a variety of developmental processes, including the patterning of the Drosophila embryo, the establishment of diverse neuronal cell types in the vertebrate neural tube, and the anterior-posterior patterning of vertebrate limbs. Here, we discuss how a gradient of the maternal transcription factor Dorsal produces complex patterns of gene expression across the dorsal-ventral (DV) axis of the early Drosophila embryo. The identification of 60-70 Dorsal target genes, along with the characterization of approximate to 35 associated regulatory DNAs, suggests that there are at least six different regulatory codes driving diverse DV expression profiles.
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