期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 105, 期 11, 页码 4465-4470出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0709504105
关键词
development; response selectivity
资金
- NIDCD NIH HHS [DC005202, R01 DC005202] Funding Source: Medline
Frequency modulated (FM) sweeps are common components of vocalizations, including human speech. How developmental experience shapes neuronal selectivity for these important signals is not well understood. Here, we show that altered developmental experience with FM sweeps used in echolocation by the pallid bat leads to either a loss of sideband inhibition or millisecond delays in the timing of inhibitory inputs, both of which lead to a reduction in rate and direction selectivity in auditory cortex. FM rate selectivity develops in an experience-independent manner, but requires experience for subsequent maintenance. Direction selectivity depends on experience for both development and maintenance. Rate and direction selectivity are affected by experience over different time periods during development. Altered inhibition may be a general mechanism of experience-dependent plasticity of selectivity for vocalizations.
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