期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 105, 期 37, 页码 13912-13917出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0710997105
关键词
antimicrobial peptides; network; reproduction
资金
- The United States-Israel Binational Agricultural Research and Development Fund [3492]
- Vigevani Fund
- Sacker Award
- The Center of Absorption in Science
- Ministry of Absorption
- The Government of Israel
- NYSTAR [C040066]
- US Department of the Army [23RYX-3275-N605]
Mating triggers physiological and behavioral changes in females. To understand how females effect these changes, we used microarray, proteomic, and comparative analyses to characterize gene expression in oviducts of mated and unmated Drosophila females. The transition from non-egg laying to egg laying elicits a distinct molecular profile in the oviduct. Immune-related transcripts and proteins involved in muscle and polarized epithelial function increase, whereas cell growth and differentiation-related genes are down-regulated. Our combined results indicate that mating triggers molecular and biochemical changes that mediate progression from a poised state to a mature, functional stage.
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