期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 105, 期 38, 页码 14615-14619出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0803652105
关键词
electron microscopy; neocortex; neuronal density; sex
资金
- Ministry of Education and Science [BFU2006-13395]
- Centro de Investigaciones Biomedicas en Red sobre Enfermedades Neurodegenerativas
- Cajal Blue Brain Project
- European Community's 6th Framework Program for Research and Technological Development [PROMEMORIA LSHM-CT-2005-512012]
Certain cognitive functions differ in men and women, although the anatomical and functional substrates underlying these differences remain unknown. Because neocortical activity is directly related with higher brain function, numerous studies have focused on the cerebral cortex when searching for possible structural correlates of cognitive gender differences. However, there are no studies on possible gender differences at the synaptic level. In the present work we have used stereological and correlative light and electron microscopy to show that men have a significantly higher synaptic density than women in all cortical layers of the temporal neocortex. These differences may represent a microanatomical substrate contributing to the functional gender differences in brain activity.
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