期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 105, 期 52, 页码 20976-20981出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0810119105
关键词
anesthesia-resistant memory; DC0 gene; learning; behavior
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan [19300137, 20019039]
- Takeda Science Foundation
- Grants-in-Aid for Scientific Research [19300137, 20019039] Funding Source: KAKEN
Increasing activity of the cAMP/protein kinase A (PKA) pathway has often been proposed as an approach to improve memory in various organisms. However, here we demonstrate that single-point mutations, which decrease PKA activity, dramatically improve aversive olfactory memory in Drosophila. These mutations do not affect formation of early memory phases or of protein synthesis-dependent long-term memory but do cause a significant increase in a specific consolidated form of memory, anesthesia-resistant memory. Significantly, heterozygotes of null mutations in PKA are sufficient to cause this memory increase. Expressing a PKA transgene in the mushroom bodies, brain structures critical for memory formation in Drosophila, reduces memory back to wildtype levels. These results indicate that although PKA is critical for formation of several memory phases, it also functions to inhibit at least one memory phase.
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