期刊
PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES
卷 85, 期 1, 页码 12-36出版社
JAPAN ACAD
DOI: 10.2183/pjab.85.12
关键词
proteasome; ubiquitin; intracellular proteolysis; multisubunit complex; molecular chaperone
资金
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan
- Target Protein Project of MEXT
- Health and Labor Science Research Grants
The proteasome is a highly sophisticated protease complex designed to carry Out selective, efficient and processive hydrolysis of client proteins. It is known to collaborate with ubiquitin, which polymerizes to form a marker For regulated proteolysis in eukaryotic cells. The highly organized proteasome plays role in the control of a diverse array of basic cellular activities by rapidly and unidirectionally catalyzing biological reactions. Studies of the proteasome during the past quarter of a century have provided profound insights into its structure and functions which has appreciably contributed to our understanding of cellular life. Many questions, however, remain to be elucidated.
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