期刊
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
卷 8, 期 1, 页码 -出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a018903
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资金
- National Institutes of Health (NIH) (Fogarty International Research Collaboration Award [FIRCA])
- Howard Hughes Medical Institute (Senior International Research Grant)
- Agencia Nacional de Promocion Cientifica y Tecnologica (PICT, Argentina)
- Swiss National Science Foundation [PP00P3-150753]
The adult hippocampus generates functional dentate granule cells (GCs) that release glutamate onto target cells in the hilus and cornus ammonis (CA) 3 region, and receive glutamatergic and gamma-aminobutyric acid (GABA) ergic inputs that tightly control their spiking activity. The slow and sequential development of their excitatory and inhibitory inputs makes them particularly relevant for information processing. Although they are still immature, new neurons are recruited by afferent activity and display increased excitability, enhanced activity-dependent plasticity of their input and output connections, and a high rate of synaptogenesis. Once fully mature, new GCs show all the hallmarks of neurons generated during development. In this review, we focus on how developing neurons remodel the adult dentate gyrus and discuss key aspects that illustrate the potential of neurogenesis as a mechanism for circuit plasticity and function.
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