期刊
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
卷 7, 期 10, 页码 -出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a018879
关键词
-
类别
资金
- Bavarian Research Network ForIPS
- BMBF Network Cell-Based Regenerative Medicine
- Interdisciplinary Center for Clinical Research of University Hospital Erlangen
- Deutsche Forschungsgemeinschaft [LI 858/9-1, BE 5136/1-1]
- National Institutes of Health (NIH) [1DP2OD006484, R01NS070981]
Adult-generated dentate granule neurons have emerged as major contributors to hippocampal plasticity. New neurons are generated from neural stem cells through a complex sequence of proliferation, differentiation, and maturation steps. Development of the new neuron is dependent on the precise temporal activity of transcription factors, which coordinate the expression of stage-specific genetic programs. Here, we review current knowledge in transcription factor-mediated regulation of mammalian neural stem cells and neurogenesis and will discuss potential mechanisms of how transcription factor networks, on one hand, allow for precise execution of the developmental sequence and, on the other hand, allow for adaptation of the rate and timing of adult neurogenesis in response to complex stimuli. Understanding transcription factor-mediated control of neuronal development will provide new insights into the mechanisms underlying neurogenesis-dependent plasticity in health and disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据