4.7 Article

Chromosomal Stress-Response Domains Govern the Spatiotemporal Expression of the Bacterial Virulence Program

期刊

MBIO
卷 6, 期 3, 页码 -

出版社

AMER SOC MICROBIOLOGY
DOI: 10.1128/mBio.00353-15

关键词

-

资金

  1. French Agence National de la Recherche (ANR)
  2. ANR Blanc Regupath
  3. Bonus Qualite Recherche (BQR) INSA de Lyon
  4. Deutsche Forschungsgemeinschaft
  5. CNRS Programme International de Cooperation Scientifique (PICS)

向作者/读者索取更多资源

Recent studies strongly suggest that the gene expression sustaining both normal and pathogenic bacterial growth is governed by the structural dynamics of the chromosome. However, the mechanistic device coordinating the chromosomal configuration with selective expression of the adaptive traits remains largely unknown. We used a holistic approach exploring the inherent relationships between the physicochemical properties of the DNA and the expression of adaptive traits, including virulence factors, in the pathogen Dickeya dadantii (formerly Erwinia chrysanthemi). In the transcriptomes obtained under adverse conditions encountered during bacterial infection, we explored the patterns of chromosomal DNA sequence organization, supercoil dynamics, and gene expression densities, together with the long-range regulatory impacts of the abundant DNA architectural proteins implicated in pathogenicity control. By integrating these data, we identified transient chromosomal domains of coherent gene expression featuring distinct couplings between DNA thermodynamic stability, supercoil dynamics, and virulence traits. IMPORTANCE We infer that the organization of transient chromosomal domains serving specific functions acts as a fundamental device for versatile adjustment of the pathogen to environmental stress. We believe that the identification of chromosomal stress-response domains harboring distinct virulence traits and mediating the cellular adaptive behavior provides a breakthrough in understanding the control mechanisms of bacterial pathogenicity.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据