期刊
PRION
卷 7, 期 1, 页码 92-97出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/pri.23806
关键词
alpha-synuclein; prion-like; Parkinson disease; cell-to-cell transfer; protein misfolding
资金
- Michael J. Fox Foundation for Parkinson Research
- Swedish Brain Foundation
- Swedish Parkinson Foundation
- Swedish Research Council
- Linnaeus grant Bagadilico
- European Research Area Network of European Funding for Neuroscience Research Program MIPROTRAN
- Human Frontier Science Program
- Swedish Brain Power
- European Research Council Advanced Award
alpha-Synuclein is a key protein in Parkinson disease. Not only is it the major protein component of Lewy bodies, but it is implicated in several cellular processes that are disrupted in Parkinson disease. Misfolded a-synuclein has also been shown to spread from cell-to-cell and, in a prion-like fashion, trigger aggregation of alpha-synuclein in the recipient cell. In this minireview we explore the evidence that misfolded alpha-synuclein underlies the spread of pathology in Parkinson disease and discuss why it should be considered a prion-like protein.
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