期刊
PRION
卷 2, 期 2, 页码 61-63出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/pri.2.2.6806
关键词
prion diseases; prion interference; prion strains
资金
- NCRR NIH HHS [C06 RR17417-01, C06 RR017417, P20 RR0115635-6] Funding Source: Medline
- NINDS NIH HHS [R01 NS052609] Funding Source: Medline
Co-inoculation of prion strains into the same host can result in interference, where replication of one strain hinders the ability of another strain to cause disease. The drowsy (DY) strain of hamster-adapted transmissible mink encephalopathy (TME) extends the incubation period or completely blocks the hyper (HY) strain of TME following intracerebral, intraperitoneal or sciatic nerve routes of inoculation. However, it is not known if the interfering effect of the DY TME agent is exclusive to the HY TME agent by these experimental routes of infection. To address this issue, we show that the DY TME agent can block hamster-adapted chronic wasting disease (HaCWD) and the 263K scrapie agent from causing disease following sciatic nerve inoculation. Additionally, per os inoculation of DY TME agent slightly extends the incubation period of per os superinfected HY TME agent. These studies suggest that prion strain interference can occur by a natural route of infection and may be a more generalized phenomenon of prion strains.
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