期刊
PREVENTIVE MEDICINE
卷 54, 期 6, 页码 434-439出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ypmed.2012.04.009
关键词
Influenza; Non-pharmacological measures; Hand hygiene; Handwashing; Transmission; Hospitalization; Prevention; Case control study; Epidemiology
Background. The objective of the study was to investigate the effectiveness of non-pharmacological interventions in preventing cases of influenza requiring hospitalization. Methods. We performed a multicenter case-control study in 36 hospitals, in 2010 in Spain. Hospitalized influenza cases confirmed by reverse-transcription polymerase chain reaction and three matched controls (two hospital and one community control) per case Were selected. The use of non-pharmacological measures seven days before the onset of symptoms (frequency of hand washing, use of alcohol-based hand sanitizers and handwashing after touching contaminated surfaces) was collected. Results. We studied 813 cases hospitalized for influenza and 2274 controls. The frequency of hand washing 5-10 times (adjusted odds ratio [aOR] = 0.65) and >10 times (aOR = 0.59) and handwashing after contact with contaminated surfaces (aOR = 0.65) were protective factors and were dose-responsive (p < 0.001). Alcohol-based hand sanitizers were associated with marginal benefits (aOR = 0.82). Conclusions. Frequent handwashing should be recommended to prevent influenza cases requiring hospitalization. (C) 2012 Elsevier Inc. All rights reserved.
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