The placental component in early-onset and late-onset preeclampsia in relation to fetal growth restriction

Objective To identify pathological placental differences between early-onset and late-onset preeclampsia, in relation to fetal growth restriction (FGR). Methods Placentas from patients with preeclampsia were analyzed for lesions of maternal vascular supply consistent with maternal underperfusion and lesions of fetal vascular supply consistent with fetal thrombo-occlusive disease. Findings were compared between patients who gave birth before 34?weeks (early-onset preeclampsia) and after 34?weeks (late-onset preeclampsia). Results Compared with the late-onset group (n?=?93), the early-onset group (n?=?37) had higher rates of FGR (62.2% vs 25.8%, P?