期刊
PRENATAL DIAGNOSIS
卷 32, 期 10, 页码 921-926出版社
WILEY-BLACKWELL
DOI: 10.1002/pd.3933
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资金
- CNPq (National Council of Technological and Scientific Development)
- FAPERGS (State of Rio Grande do Sul Agency for Research Support)
- FAPICC (Institute of Cardiology Fund for Research and Culture Support), Brazil
Objectives The aim of this study was to test the hypothesis that experimental maternal intake of green tea in late pregnancy causes fetal ductus arteriosus constriction, probably because of prostaglandin inhibition. Methods and Results Twelve fetal lambs (pregnancy>120days) were assessed before and after maternal administration of green tea (n=8) or water (n=4; controls) as the only source of liquid. After 1week, echocardiography showed signs of constriction of the ductus arteriosus in all fetuses from mothers ingesting green tea, with increase in mean systolic velocity(from 0.70+/-0.19m/s to 0.92+/-0.15m/s, 31.4%, p=0.001) and mean diastolic velocity (0.19+/-0.05m/s to 0.31+/-0.01m/s, 63.1%, p<0.001), decrease of pulsatility index (2.2+/-0.4 to 1.8+/-0.3, 22.2%, p=0.003) and increase of mean right ventricular/left ventricular diameter ratio (0.89+/-0.14 to 1.43+/-0.23, 60.6%, p<0.001). In the four control fetuses, there were no significant changes. All lambs exposed to green tea also showed at autopsy dilated and hypertrophic right ventricles, which was not present in control fetuses. Histological analysis showed a significantly larger mean thickness of the medial avascular zone of the ductus arteriosus in fetuses exposed to green tea than in controls (747.6+/-214.6 mu m vs 255.3+/-97.9 mu m, p<0.001). Conclusions This study in fetal lambs shows a cause and effect relationship between experimental maternal exposure of green tea and fetal ductus arteriosus constriction in late pregnancy. (c) 2012 John Wiley & Sons, Ltd.
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